A research published in the scientific journal Nutrition & Metabolism studied the effects of a combination of three very well know nutritional supplements: L Carnitine, Creatine and Leucine on muscle mass and performance in older subjects with sedentary lifestyle.
Forty-two healthy older adults aged 55–70 years were randomized to receive either a combination of L-Carnitine (1500 mg), L-leucine (2000 mg), creatine (3000 mg), or a placebo for eight weeks.
The study subjects were: healthy males and females between the ages 55–70 years with sedentary lifestyle. The subjects were oriented to maintain current dietary habits and activity levels. No exercise or training program was applied.
The authors evaluated muscle mass, functional strength and mobility after eight weeks of intervention.
Quality of life, blood safety markers, and muscle biopsies for protein synthesis analysis were also conducted at baseline and the end of the study.
In conclusion, L-Carnitine in combination with L-leucine and creatine, significantly enhanced lean muscle mass and functional strength particularly in the lower legs, likely due to an improved muscle protein synthesis.
The combination product was safe, well tolerated, and may provide additional performance value with prolonged use beyond the 8-week study period in healthy older adults.