What role does Leptin and Ghrelin play in the regulation of food intake and body weight in humans?
The researchers of the Department of Endocrinology, University Medical Center in Amsterdam, the Netherlands published an article about two of the hormones that are regulated by the ingredients of the Lean Machine of Midwaylabs Glamour Nutrition line.
Leptin and ghrelin are two hormones that have been recognized to have a major influence on energy balance. Leptin is a mediator of long-term regulation of energy balance, suppressing food intake and thereby inducing weight loss.
Ghrelin on the other hand, is a fast-acting hormone, seemingly playing a role in meal initiation. Ghrelin is responsible for increasing the growth hormone, GH, Plasma ghrelin concentration alters throughout the day. Its level is maximum in the fasting state, before meals, and at night, falling within one hour of a meal.
Fat seems to decrease ghrelin less effectively per calorie than carbohydrate or protein. This may elucidate the reduced satiety and increased weight gain connected with high-fat diets to some extent.
As a growing number of people suffer from obesity, understanding the mechanisms by which various hormones and neurotransmitters have influence on energy balance has been a subject of intensive research.
Avicenna J Phyttomed. 2015 Jul-Aug; 5(4): 271–281.
Obes Rev 2007 Jan;8(1):21-34